Name: Sávio Cabral Lopes de Lima
Type: MSc dissertation
Publication date: 27/02/2020
Advisor:
Name |
Role |
|---|---|
| Maria do Carmo Pimentel Batitucci | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| Hildegardo Seibert França | Internal Examiner * |
| JEAN CARLOS VENCIONECK DUTRA | External Examiner * |
| Juliana Macedo Delarmelina | External Alternate * |
| Maria do Carmo Pimentel Batitucci | Advisor * |
| Silvia Tamie Matsumoto | Internal Alternate * |
Summary: The Schinus terebinthifolius Raddi belong to the Anacardiaceae family, popularly known as aroeira and pink pepper, is native from South America, and is present in popular culture and knowledge as a medicinal plant with healing and anti-inflammatory potential. The fruits are used as a culinary condiment in Brazil and even more so in European countries and North American, to which they are exported, therefore, they have significant economic importance. The leaves and the bark are used in infusions and decoctions by people without any evaluation and safety in consumption, which can cause damage to health, since studies have found a series of secondary metabolites with beneficial and harmful actions to human health, among them flavonoids, tannins, alkaloids, coumarins and terpenes. In this context, four different antioxidant tests of the ethanolic extract of five clonal genotypes provided by INCAPER (Institute of Rural Research and Extension) were carried out, based on the results obtained, a low antioxidant activity of the extracts is observed, except for the FRAP test, in which the IC50 values are close to that found in the standard. In the cell viability assay (MTT), significant cytotoxicity was found in the 48-hour exposure treatments, especially with regard to lymphocytes. A data worth mentioning is that the concentration of 10 μg / mL of the extracts that promotes a proliferative action of Sarcoma 180 cells, after exposure for 48 hours. The anti-cytotoxic test shows that all genotypes have good preventive activity, as well as demonstrating a significant increase in cell viability after treatment. Concluding then, that the extract of the aroeira fruit, in certain concentrations, can be cytotoxic and even cause the proliferation of tumor cells, however, they also seem to work in preventing damage to cells as well as in cell recovery.
